Effects of acid-base imbalance on vascular reactivity

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Effects of acid-base imbalance on vascular reactivity.

Acid-base homeostasis maintains systemic arterial pH within a narrow range. Whereas the normal range of pH for clinical laboratories is 7.35-7.45, in vivo pH is maintained within a much narrower range. In clinical and experimental settings, blood pH can vary in response to respiratory or renal impairment. This altered pH promotes changes in vascular smooth muscle tone with impact on circulation...

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Humans generally consume a diet that generates metabolic acids leading to a reduction in the concentration of systemic bicarbonate and a fall in pH. In vitro experiments indicate that this metabolic acidosis causes a release of calcium from bone that initially is simply due to physicochemical dissolution of the mineral. On a more chronic basis metabolic acidosis alters bone cell function; there...

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SINCE the introduction of external cardiac massage the technique and results of cardiac resuscitation have received much attention, but less information is available on the effect of cardiac arrest on respiration and circulation. The authors, who provided a resuscitation service for a general hospital, were particularly interested in these aspects and in thirty-eight of the first 100 patients t...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2008

ISSN: 1414-431X,0100-879X

DOI: 10.1590/s0100-879x2008005000026